Studies of Neuregulin/ERBB Signaling in Human Heart

This study is examining heart tissue from patients undergoing open-heart bypass surgery to learn more about a specific protein signaling system — called Neuregulin/ERBB — that may play an important role in heart health and disease. **You may be eligible if...** - You have been diagnosed with severe coronary artery disease (significant blockages in the blood vessels that supply the heart) - You are already scheduled to have coronary artery bypass surgery — a major heart operation to reroute blood flow around blocked arteries **You may NOT be eligible if...** - You are under 18 years old - You are unable or unwilling to give consent - You have active inflammation of the heart muscle (myocarditis) - You have a condition where the heart muscle is abnormally thickened (hypertrophic cardiomyopathy) - You have significant disease of the sac surrounding the heart - You have severe high blood pressure in the lungs - Your kidneys are significantly impaired - You have severe irregular heart rhythms - You are pregnant Talk to your doctor to see if this trial is right for you.