RecruitingNot ApplicableNCT02864485

Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

Assessment of a Protocol Using a Combination of Neo-adjuvant Chemotherapy Plus Living Donor Liver Transplantation for Non-Resectable Liver Metastases From Colorectal Cancer

Sponsor

University Health Network, Toronto

Enrollment

20 participants

Start Date

Aug 3, 2016

Study Type

INTERVENTIONAL

Conditions

Colorectal, Cancer Liver Metastases

Summary

Patients with unresectable liver metastases (LM) from colorectal cancer (CRC)have a poor prognosis. In patients with resectable disease, surgery offers a distinct survival benefit. This study will offer live donor liver transplantation (LDLT) to select patients with unresectable metastases that are 1) limited to the liver and 2) stable (non-progressing) on standard chemotherapy. Potential participants will be evaluated for liver transplant suitability and must also have a willing, healthy living donor come forward for evaluation. Those participants who undergo LDLT will be followed for survival, disease-free survival and quality of life for 5 years and compared to a "control group" of participants who drop out of study prior to transplantation due to reasons other than cancer progression.

Eligibility

Min Age: 18 YearsMax Age: 68 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a liver transplant using a liver donated by a living person can help patients in Canada whose colorectal cancer has spread only to the liver and cannot be removed by standard surgery, offering a potentially life-extending option beyond chemotherapy alone. **You may be eligible if...** - You live in Canada - You have confirmed colorectal cancer that has spread only to the liver and not elsewhere - The liver tumors are in both lobes and cannot be surgically removed - Your original colorectal cancer surgery was at least 6 months ago - You have already received chemotherapy for the liver metastases - You are in good overall health and able to function independently - A compatible and willing living donor has come forward - You agree to use appropriate contraception during the trial **You may NOT be eligible if...** - The cancer has spread outside the liver - You do not have a willing and compatible living donor - Your original colorectal tumor was at an advanced stage beyond T4a - You are not well enough to undergo major transplant surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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