Liver Metastases Clinical Trials

76 recruitingLast updated: June 17, 2026

There are 76 actively recruiting liver metastases clinical trials across 22 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1. Top locations include Amsterdam, Netherlands, Toronto, Ontario, Canada, Guangzhou, Guangdong, China. Updated daily from ClinicalTrials.gov.


Liver Metastases Trials at a Glance

76 actively recruiting trials for liver metastases are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Not Applicable with 23 trials, with the heaviest enrollment activity in Amsterdam, Toronto, and Guangzhou. Lead sponsors running liver metastases studies include Fudan University, Amsterdam UMC, location VUmc, and Assistance Publique - Hôpitaux de Paris.

Browse liver metastases trials by phase

Treatments under study

About Liver Metastases Clinical Trials

Looking for clinical trials for Liver Metastases? There are currently 54 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Liver Metastases trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Liver Metastases clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 76 trials

Recruiting
Phase 1Phase 2

Safety of HRX215 in Patients After Minor and Major Liver Resection

Liver ResectionColorectal Carcinoma Liver Metastases
HepaRegeniX GmbH80 enrolled6 locationsNCT06638502
Recruiting
Not Applicable

OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases

Liver MetastasesStereotactic Body Radiation TherapyMRI-guided Treatment
University of Wisconsin, Madison32 enrolled1 locationNCT04020276
Recruiting

FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases

Antineoplastic Combined Chemotherapy ProtocolsRectal CancerSynchronous Liver Metastases+1 more
Assistance Publique - Hôpitaux de Paris550 enrolled1 locationNCT07467434
Recruiting
Not Applicable

Proton Therapy in the Treatment of Liver Metastases

Liver Metastases
Loma Linda University35 enrolled1 locationNCT01697371
Recruiting
Phase 1Phase 2

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

Metastatic MelanomaLiver Metastases
University of Wisconsin, Madison15 enrolled1 locationNCT07281924
Recruiting
Not Applicable

Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research

Colorectal, CancerLiver MetastasesGenetic Change
Hospital Vall d'Hebron35 enrolled1 locationNCT05398380
Recruiting

China Metastatic Liver Cancer Clinical Registry Cohort Database

Liver CancerLiver MetastasesNeoplasms+3 more
Anhui Provincial Hospital2,000 enrolled3 locationsNCT07602504
Recruiting
Phase 2

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Colorectal, CancerLiver MetastasesColorectal Cancer Metastatic
Weill Medical College of Cornell University24 enrolled1 locationNCT06300463
Recruiting
Early Phase 1

Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases

Stage, Colon CancerStage I-III Colon CancerStage IV Colon Cancer With Resectable Liver Metastases
Dana-Farber Cancer Institute80 enrolled1 locationNCT02172651
Recruiting
Not Applicable

Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery

Pancreatic CancerLiver MetastasesPancreatic Neoplasm
University of Aarhus200 enrolled3 locationsNCT05428358
Recruiting
Phase 2

AK104 Plus Radiotherapy Combined With Standard Therapy Versus Standard Therapy as First-Line Treatment for pMMR/MSS CRLM (APSOC)

Colorectal Cancer Liver Metastases (CRLM)
Fudan University73 enrolled1 locationNCT07544784
Recruiting
Phase 2Phase 3

Neoadjuvant Serplulimab & Bevacizumab With FOLFOX vs. FOLFOX Alone in RAS/BRAF WT, pMMR/MSS CRC Patients

Colorectal, CancerLiver Metastases
Sun Yat-sen University156 enrolled1 locationNCT06280495
Recruiting
Not Applicable

Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis

Liver CancerColorectal, CancerLiver Metastases
Case Comprehensive Cancer Center100 enrolled1 locationNCT07044362
Recruiting
Phase 2Phase 3

Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment

Liver Metastases
Memorial Sloan Kettering Cancer Center200 enrolled1 locationNCT04143516
Recruiting
Phase 3

Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction

Liver Metastases
University Health Network, Toronto114 enrolled1 locationNCT06362395
Recruiting

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Breast CancerLiver CancerEsophageal Cancer+35 more
UMC Utrecht8,000 enrolled18 locationsNCT04075305
Recruiting
Phase 2

SCRT(Short Course Radiotherapy) Combined With CAPOX Plus QL1706 for Rectal Cancer Liver Metastases

Locally Advanced Rectal Cancer With Liver Metastases
Fujian Cancer Hospital42 enrolled2 locationsNCT06787183
Recruiting
Not Applicable

Promoting Immunotherapy Efficacy With Low-Dose Liver RT

MelanomaNon-small Cell Lung CancerLiver Metastases+1 more
Jordan Kharofa21 enrolled1 locationNCT07225036
Recruiting
Not Applicable

Sonoporation and Tumor Microenvironment Response in Colorectal Liver Metastases

Liver Metastases From Colorectal Cancer
Zealand University Hospital48 enrolled2 locationsNCT07365527
Recruiting
Phase 2

A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

Colorectal, CancerLiver Metastases
Memorial Sloan Kettering Cancer Center32 enrolled7 locationsNCT06130280