RecruitingNot ApplicableNCT02902198
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
Sponsor
University Hospital, Basel, Switzerland
Enrollment
16 participants
Start Date
Dec 1, 2014
Study Type
INTERVENTIONAL
Conditions
Summary
The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
Eligibility
Min Age: 18 YearsMax Age: 55 Years
Inclusion Criteria2
- morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
- right handed
Exclusion Criteria2
- cardiovascular disease
- neurologic/psychiatric disorders
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Interventions
DIETARY_SUPPLEMENTPlacebo
Tap water 200ml
DIETARY_SUPPLEMENTGlucose
25g Glucose in 200ml tap water
DIETARY_SUPPLEMENTMonosodium glutamate
1g monosodium glutamate in 200ml tap water
DIETARY_SUPPLEMENTQuinine
17mg quinine in 200ml tap water
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT02902198
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