RecruitingNCT02964637

Diagnosing Frontotemporal Lobar Degeneration

Multimodal Assessment for Predicting Specific Pathological Substrate in Frontotemporal Lobar Degeneration

Sponsor

University Health Network, Toronto

Enrollment

100 participants

Start Date

Aug 1, 2015

Study Type

OBSERVATIONAL

Conditions

Corticobasal Syndrome Progressive Supranuclear Palsy Semantic Dementia Progressive Nonfluent Aphasia Behavioral Variant Frontotemporal Dementia Amyotrophic Lateral Sclerosis And/or Frontotemporal Dementia

Summary

To establish diagnostic tools to make an accurate clinical and pathological diagnosis of patients with clinical FTLD syndromes

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria3

Participant must have a reliable study partner who can provide an independent evaluation of functioning.
Able to read, understand and speak English for neuropsychological testing.
Control subjects must have a normal neurological exam, a CDR sum of boxes = 0, and MMSE score equal to or greater than 28

Exclusion Criteria4

Patients with clinical, imaging or CSF A beta/ tau profile consistent with AD
History of traumatic brain injury, brain tumors, stroke or other neurological or psychiatric disorders that can explain symptoms will be excluded.
Premenopausal women will be asked to consent to a pregnancy test prior to each scan as pregnant women will be excluded from study because of potential harm to fetus from PET study.
Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body.

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Interventions

OTHERObservational Study

Locations(1)

Toronto Western Hospital, University Health Network

Toronto, Ontario, Canada

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NCT02964637

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