Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

This study is using brain scans to better understand Parkinson's disease (PD). Researchers want to identify imaging markers that can predict how fast someone's Parkinson's will progress, and also help distinguish Parkinson's from similar-looking conditions like Lewy body dementia or other movement disorders. **You may be eligible if...** - You have a confirmed diagnosis of Parkinson's disease - You were diagnosed with PD less than 5 years ago (for the longitudinal arm) - You are willing to have brain scans and return for follow-up visits over 2 years - You have a related movement disorder such as MSA or PSP and are willing to participate - Or you are a healthy volunteer willing to have brain scans for comparison **You may NOT be eligible if...** - You are unable to tolerate MRI or PET brain scans - You have other significant neurological conditions unrelated to Parkinson's - You are unable to return for required follow-up visits Talk to your doctor to see if this trial is right for you.