RecruitingPhase 2NCT02974647

Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

Phase II Multicenter Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

83 participants

Start Date

Nov 1, 2016

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test any good and bad effects of the study drug called ruxolitinib. Ruxolitinib works by blocking a protein called JAK. JAK works along with another protein called STAT and is important for survival of many T or NK-cell lymphomas. By blocking JAK, ruxolitinib may cause T or NK-cell lymphomas to shrink.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a drug called ruxolitinib in patients with T-cell or NK-cell lymphoma (types of immune system cancers) that have come back or stopped responding to previous treatments. **You may be eligible if...** - You have been confirmed to have a T-cell or NK-cell lymphoma at the study site - Your cancer has relapsed or stopped responding to at least one prior treatment (with some exceptions for specific subtypes) - You are 18 years of age or older - Your general health is good enough to participate (ECOG score 0–2) - Your cancer can be measured on imaging or skin exams - Your organ function (blood, liver, kidneys) meets the required levels **You may NOT be eligible if...** - You have had more than 3 prior lines of treatment (depending on the subtype) - You have uncontrolled infection or serious other illnesses - You are pregnant or breastfeeding - You are taking medications that could interact with ruxolitinib Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRuxolitinib

Locations(10)

University of Miami

Miami, Florida, United States

Northwestern Medicine (Data collection and specimen analysis)

Chicago, Illinois, United States

Dana Farber Cancer Institute

Boston, Massachusetts, United States

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, United States

Memorial Sloan Kettering Monmouth (All Protocol Activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Commack

Commack, New York, United States

Memorial Sloan Kettering Westchester

Harrison, New York, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Weill Cornell Medical College

New York, New York, United States

Memorial Sloan Kettering Nassau (All Protocol Activities)

Uniondale, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT02974647


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