Lymphoma Clinical Trials

191 recruiting

Lymphoma Trials at a Glance

1,135 actively recruiting trials for lymphoma are listed on ClinicalTrialsFinder across 6 cities in 69 countries. The largest study group is Phase 2 with 533 trials, with the heaviest enrollment activity in New York, Houston, and Boston. Lead sponsors running lymphoma studies include National Cancer Institute (NCI), M.D. Anderson Cancer Center, and City of Hope Medical Center.

Treatments under study

Understanding Lymphoma Clinical Trials

Rituximab (Rituxan), first approved in 1997 after pivotal clinical trials, fundamentally changed the treatment of B-cell lymphomas and remains a cornerstone of therapy decades later. Since then, clinical trials have delivered additional breakthroughs including brentuximab vedotin for Hodgkin lymphoma, polatuzumab vedotin for diffuse large B-cell lymphoma, and CAR-T cell therapies like axicabtagene ciloleucel (Yescarta) for patients with relapsed aggressive lymphoma. With over 70 subtypes of lymphoma, clinical trials are essential for developing treatments tailored to specific disease biology, and many patients with lymphoma have access to promising new therapies only through trial participation.

Why Consider a Clinical Trial?

Lymphoma is not a single disease — it includes Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, and many other subtypes, each with distinct behavior and treatment needs. While some lymphomas respond well to standard chemoimmunotherapy, others are harder to treat, and patients whose lymphoma returns after initial treatment face limited options. Clinical trials can provide access to next-generation antibodies, antibody-drug conjugates, bispecific antibodies, and cellular therapies that may be more effective or less toxic than existing treatments. Participation in a lymphoma trial also means your care is guided by a detailed protocol developed by leading experts and reviewed by multiple regulatory bodies. You receive close monitoring, including frequent imaging and blood work, that can detect changes in your disease earlier than routine follow-up schedules. For patients with indolent (slow-growing) lymphomas who are on a watch-and-wait approach, there are trials studying whether early intervention with novel agents can delay or prevent the need for chemotherapy altogether.

Frequently Asked Questions

Common questions about Lymphoma clinical trials

Yes. Hodgkin lymphoma and non-Hodgkin lymphoma are biologically distinct diseases with different treatment approaches, so they have separate clinical trials. Non-Hodgkin lymphoma trials are further divided by subtype, such as diffuse large B-cell lymphoma or follicular lymphoma. Your specific subtype determines which trials you are eligible for.

Yes. Some trials focus specifically on patients in remission, studying maintenance therapies or monitoring strategies designed to prevent relapse. There are also survivorship trials that address long-term side effects of treatment. Ask your oncologist about trials that match your current disease status.

It is extremely rare for a lymphoma trial to have a placebo-only group. Most trials compare the new treatment plus standard therapy against standard therapy alone, or compare two active treatments. You will always know before enrolling whether the trial includes a placebo component.

Many trials require a fresh biopsy, especially if your most recent one is older than a few months or if you have received treatment since your last biopsy. This is because lymphoma biology can change over time or after treatment. The biopsy helps confirm your subtype and test for biomarkers that determine trial eligibility.

Many academic cancer centers offer virtual pre-screening consultations to determine if you might qualify before you travel. Some trials allow portions of treatment and monitoring to be done at a local oncologist through satellite site arrangements. Ask the trial coordinator about remote participation options and travel reimbursement programs.

Showing 120 of 1,135 trials

Recruiting
Phase 3

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular LymphomaFollicular Lymphoma With Unusual Cytological Features
National Cancer Institute (NCI)600 enrolled261 locationsNCT06337318
Recruiting
Phase 1

A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer (NSCLC)Anaplastic Lymphoma Kinase (ALK) Positive
Astellas Pharma Global Development, Inc.40 enrolled15 locationsNCT07140016
Recruiting

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

LymphomasHIVKaposi's Sarcoma
National Cancer Institute (NCI)1,029 enrolled1 locationNCT00006518
Recruiting
Phase 1

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
National Cancer Institute (NCI)47 enrolled54 locationsNCT04609046
Recruiting
Phase 2

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRefractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRecurrent Diffuse Large B-Cell Lymphoma+12 more
National Cancer Institute (NCI)120 enrolled82 locationsNCT06649812
Recruiting

Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

Small Lymphocytic LymphomaWaldenstrom MacroglobulinemiaLymphoplasmacytic Lymphoma+2 more
National Heart, Lung, and Blood Institute (NHLBI)1,000 enrolled1 locationNCT00923507
Recruiting

Cognitive Aftereffects of Neurotoxicity in Children and Young Adults With Relapsed/Refractory Hematologic Malignancies Who Receive CAR T-cell Therapy

LymphomaLeukemia
National Cancer Institute (NCI)60 enrolled3 locationsNCT05237986
Recruiting
Phase 3

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
National Cancer Institute (NCI)247 enrolled629 locationsNCT04269902
Recruiting
Phase 3

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
National Cancer Institute (NCI)1,875 enrolled403 locationsNCT05675410
Recruiting
Phase 2

Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease

Lymphoma, Primary Effusion
National Cancer Institute (NCI)28 enrolled1 locationNCT05907759
Recruiting
Phase 4

Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma

Acute Lymphoblastic LeukemiaMixed Phenotype Acute LeukemiaLymphoblastic Lymphoma
St. Jude Children's Research Hospital850 enrolled3 locationsNCT06289673
Recruiting
Phase 2

Therapy for Newly Diagnosed Patients With B-Cell Precursor Acute Lymphoblastic Leukemia and Lymphoma

Acute Lymphoblastic LeukemiaLymphoblastic Lymphoma
St. Jude Children's Research Hospital128 enrolled2 locationsNCT06533748
Recruiting
Phase 1

Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
National Cancer Institute (NCI)30 enrolled8 locationsNCT06015880
Recruiting
Phase 2

Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRefractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Fred Hutchinson Cancer Center20 enrolled1 locationNCT07194980
Recruiting
Phase 2

PD-1 Inhibitors Maintenance for cHL Post-autoHCT

Hodgkin Lymphoma
St. Petersburg State Pavlov Medical University83 enrolled4 locationsNCT06812858
Recruiting
Phase 2

Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)

T-cell LymphomaT-cell Acute Lymphoblastic LeukemiaMixed Phenotype Acute Leukemia
St. Jude Children's Research Hospital100 enrolled3 locationsNCT06390319
Recruiting

Tissue Collection for Studies of Lymph Cancer

Multiple MyelomaLymphoma, Non-HodgkinLeukemia-Lymphoma, Adult T-Cell+2 more
National Cancer Institute (NCI)1,295 enrolled2 locationsNCT01676805
Recruiting

Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

Chronic Lymphocytic Leukemia (CLL)Hairy Cell Leukemia (HCL)Non-Hodgkins Lymphoma (NHL)+2 more
National Cancer Institute (NCI)1,263 enrolled1 locationNCT01087333
Recruiting
Phase 1Phase 2

Pralatrexate With Bendamustine and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma

Recurrent T-Cell Non-Hodgkin LymphomaRefractory T-Cell Non-Hodgkin Lymphoma
Fred Hutchinson Cancer Center50 enrolled1 locationNCT07225985
Recruiting
Phase 1

Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid in Combination With Polatuzumab (ViPOR-P) in Relapsed/Refractory B-cell Lymphoma

Non-Hodgkin LymphomaLymphoma
National Cancer Institute (NCI)55 enrolled1 locationNCT04739813