RecruitingEarly Phase 1NCT02982902

T Cell Therapy of Opportunistic Cytomegalovirus Infection

Antigen Specific Adoptive T Cell Therapy for Opportunistic Cytomegalovirus Infection Occurring After Stem Cell Transplant


Sponsor

Mari Dallas

Enrollment

20 participants

Start Date

May 27, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine if a specific type of cell-based immunotherapy, using T-cells from a donor that are specific against cytomegalovirus (CMV) is feasible to treat infections by CMV. Adoptive T-cell therapy is an investigational (experimental) therapy that works by using the blood of a donor and selecting the T-cells that can respond against a specific infectious entity. These selected T-cells are then infused to the patient, to try to give the immune system the ability to fight the infection. Adoptive T-cell therapy is experimental because it is not approved by the Food and Drug Administration (FDA).


Eligibility

Min Age: 3 Months

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a biological treatment called CMV specific adoptive t-cells for people with cytomegalovirus infections, hematopoietic stem cell transplant, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCMV specific adoptive t-cells

It is expected that the cell dose will be in the range of 10\^3 - 10\^5 virus - specific, antigen selected T cells per kg of recipient weight.


Locations(1)

University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center

Cleveland, Ohio, United States

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NCT02982902


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