Prognostic and Predictive Biomarkers in Ovarian Cancers
Gustave Roussy, Cancer Campus, Grand Paris
350 participants
Sep 26, 2016
INTERVENTIONAL
Conditions
Summary
The investigators therefore propose to conduct a biological study of prospectively collected patient tumour samples, ascites, blood and other residual samples (feces, urine, vaginal smear) throughout the disease course where markers (at diagnosis and their change with treatment) will be correlated to outcome in order to investigate how genetic diversity in OC prior to treatment and adaptation following treatment contribute to chemotherapy resistance. In addition freshly collected ascitic samples (and tumour samples) will be subjected to ex vivo DNA repair functional assays and isolated in primary culture (and established as xenografts) for target validation experiments.
Eligibility
Inclusion Criteria7
- New patient with a diagnosis of OC, or
- Previously treated patient with frozen or formalin fixed paraffin embedded primary tumour sample available that can be retrieved by the center presenting with progressive disease, and consenting to CT guided biopsy of relapsed disease, or
- Previously treated patient with frozen or formalin fixed paraffin embedded primary tumour sample available that can be retrieved by the center scheduled for surgery for relapsed disease.
- Signed informed consent
- Age ≥ 18
- Patient affiliated to a social security regimen or beneficiary of the same
- Coagulation abnormalities that contra-indicates the biopsy
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT03010124