RecruitingNot ApplicableNCT03010124

Prognostic and Predictive Biomarkers in Ovarian Cancers

Sponsor

Gustave Roussy, Cancer Campus, Grand Paris

Enrollment

350 participants

Start Date

Sep 26, 2016

Study Type

INTERVENTIONAL

Conditions

Ovarian Cancer

Summary

The investigators therefore propose to conduct a biological study of prospectively collected patient tumour samples, ascites, blood and other residual samples (feces, urine, vaginal smear) throughout the disease course where markers (at diagnosis and their change with treatment) will be correlated to outcome in order to investigate how genetic diversity in OC prior to treatment and adaptation following treatment contribute to chemotherapy resistance. In addition freshly collected ascitic samples (and tumour samples) will be subjected to ex vivo DNA repair functional assays and isolated in primary culture (and established as xenografts) for target validation experiments.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting tumor samples and tracking outcomes in patients with ovarian cancer to identify biological markers that can predict how a patient will respond to treatment and whether the cancer is likely to return. **You may be eligible if...** - You are newly diagnosed with ovarian cancer, OR - You have been previously treated for ovarian cancer and your disease has come back, and you have tumor tissue available from your original diagnosis AND you are willing to have a new biopsy of the recurrent tumor, OR - You are a previously treated patient with available tumor tissue who is scheduled for surgery to treat the recurrence - You are able to give informed consent **You may NOT be eligible if...** - You do not have a confirmed diagnosis of ovarian cancer - You do not have tumor tissue available and are not willing or able to undergo a biopsy - You are unable to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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