Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer

This trial tests whether giving immune checkpoint inhibitor drugs (a type of immunotherapy) before surgery can help the immune system attack early-stage colon cancer, potentially reducing the need for extensive treatment afterward. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of non-metastatic colon cancer (cancer that has not spread to other organs) - Your cancer has not caused a blockage, major bleeding, or suspected perforation of the bowel - You have not previously been treated with immunotherapy drugs - You are in good physical condition (WHO performance status 0 or 1) - You are willing to have a colonoscopy to collect tissue samples for the study **You may NOT be eligible if...** - You have an autoimmune disease (a condition where the immune system attacks the body) - You are on immune-suppressing medications such as high-dose steroids - You have active hepatitis B or C - You have had radiation therapy to the same area, or radiation is planned after surgery - You have received a live vaccine within 4 weeks of joining - You have significant heart disease or active infection Talk to your doctor to see if this trial is right for you.