Local Therapy in Advanced NSCLC With Non-progressive Disease (PD) After First Line Therapy

This trial investigates whether adding local treatments (such as radiation or surgery) directly to tumor sites in people with advanced non-small cell lung cancer (NSCLC) — whose disease has been controlled but not fully eliminated by first-line therapy — can extend the time before the cancer grows again. **You may be eligible if...** - You are 18 or older with confirmed stage IV (metastatic) non-small cell lung cancer - Your cancer responded to or was stabilized by first-line treatment (chemotherapy, targeted therapy, or immunotherapy) - You have 5 or fewer metastatic tumor sites (limited spread) - You are in reasonably good health (ECOG performance status 0–2) - Your blood counts, liver, and kidney function meet required levels **You may NOT be eligible if...** - Your cancer came back and was already treated with a second round of therapy - Your disease progressed within 3 months of starting first-line treatment - You have had another cancer within the past 5 years (other than certain skin cancers) - You have HIV, an active serious infection, or unstable heart or liver disease - You are pregnant, breastfeeding, or unwilling to use contraception Talk to your doctor to see if this trial is right for you.