A Phase I/II Multiple Center Trial of 4SCAR19 Cells in the Treatment of Relapsed and Refractory B Cell Malignancies

This trial tests a CAR T-cell therapy — where a patient's own immune cells are reprogrammed in a lab to recognize and attack cancer — in people with B-cell blood cancers (a type of cancer affecting white blood cells) that have come back or not responded to other treatments. **You may be eligible if...** - You are older than 6 months - Your cancer cells have a marker called CD19 on their surface (this is a type of B-cell cancer) - You are in reasonably good health overall (KPS score over 80) with a life expectancy of more than 3 months - Your hemoglobin (red blood cell level) is above 80 g/L **You may NOT be eligible if...** - You have another serious active disease that cannot be controlled - You have an active bacterial, fungal, or viral infection that is not controlled - You are HIV positive - You have active hepatitis B or C - You are pregnant or breastfeeding - You took systemic steroid medications (like prednisone) within the past week - You have already tried CAR T-cell therapy and it did not work Talk to your doctor to see if this trial is right for you.