RecruitingPhase 1Phase 2NCT03125577

Combination CAR-T Cell Therapy Targeting Hematological Malignancies

Combination CAR-T Therapy of 4SCAR19 Plus 4SCAR20, 22, 38, 70 and 123 Targeting Hematological Malignancies


Sponsor

Shenzhen Geno-Immune Medical Institute

Enrollment

100 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The study will evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting CD19 (4SCAR19) and CD20 (4SCAR20), CD22 (4SCAR22), CD30 (4SCAR30), CD38 (4SCAR38), CD70 (4SCAR70) or CD123 (4SCAR123) for patients with B cell malignancies. Clinical response and development of a standardized lentiviral vector and cell production protocol will be investigated. This is a phase I/II trial enrolling patients from multiple clinical centers.


Eligibility

Min Age: 6 MonthsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a new approach using specially engineered immune cells (called CAR-T cells) that are designed to attack several different proteins found on blood cancer cells at the same time. **You may be eligible if...** - You are older than 6 months - You have a blood cancer involving B cells that carry certain proteins on the surface (CD19, CD20, CD22, CD30, CD38, CD70, or CD123) - Your general health is reasonably good (KPS score over 80) and you are expected to live more than one month - Your hemoglobin level is above 80 g/L - You have no medical reason that prevents blood cell collection **You may NOT be eligible if...** - You have another active serious illness that would make it hard to judge how the treatment is working - You have an uncontrolled bacterial, fungal, or viral infection - You are living with HIV Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICAL4SCAR19 and 4SCAR22

4SCAR19 and 4SCAR22

BIOLOGICAL4SCAR19 and 4SCAR38

4SCAR19 and 4SCAR38

BIOLOGICAL4SCAR19 and 4SCAR20

4SCAR19 and 4SCAR20

BIOLOGICAL4SCAR19 and 4SCAR123

4SCAR19 and 4SCAR123

BIOLOGICAL4SCAR19 and 4SCAR70

4SCAR19 and 4SCAR70

BIOLOGICAL4SCAR19 and 4SCAR30

4SCAR19 and 4SCAR30


Locations(4)

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Shenzhen Geno-immune Medical Institute

Shenzhen, Guangdong, China

Yunnan Cancer Hospital & The Third Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center

Kunming, Yunnan, China

View Full Details on ClinicalTrials.gov

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NCT03125577


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