Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

This study offers a bone marrow transplant from a partially matched family donor for children and young adults who have serious non-cancerous conditions that require transplantation — such as sickle cell disease, bone marrow failure syndromes, metabolic disorders, or immune system disorders — and who do not have a fully matched sibling donor available. You may be eligible if: - You are 21 years old or younger - You have a serious non-malignant disorder that requires a bone marrow transplant (e.g., sickle cell disease, aplastic anemia, a metabolic or immune disorder) - You do not have a fully matched sibling donor but do have a partially matched family member willing to donate - Your heart, lung, kidney, and liver function meet minimum requirements - For sickle cell disease: you must have experienced certain severe complications (stroke, recurrent chest syndrome, kidney disease, severe pain episodes, etc.) You may NOT be eligible if: - You have a fully matched sibling donor available - You have liver cirrhosis, active hepatitis, or have recently had an uncontrolled serious infection - You are HIV-positive - You have had a previous stem cell transplant - You are pregnant or breastfeeding - You have active autoimmune disease (e.g., lupus, scleroderma) Talk to your doctor to see if this trial is right for you.