RecruitingNot ApplicableNCT03184038

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery: A Phase II Study

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Enrollment

90 participants

Start Date

Feb 21, 2017

Study Type

INTERVENTIONAL

Conditions

Metastatic Malignant Solid Neoplasm Metastatic Malignant Neoplasm in the Brain

Summary

This phase II trial studies the neurological function in patients with multiple brain metastases undergoing stereotactic radiosurgery (SRS) or stereotactic body radiation therapy (SBRT). Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method can kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Assessment of neurocognitive function may help show that SRS preserves neurological function in patients with multiple brain metastases better than SBRT.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a highly precise type of brain radiation called radiosurgery (which targets tumors without open surgery) affects memory, thinking, and quality of life in people who have multiple cancer tumors that have spread to the brain. **You may be eligible if...** - You have a solid tumor cancer (not small cell lung cancer or germ cell tumors) that has spread to 1–10 spots in the brain - No more than 2 brain tumors are larger than 3 cm, and none are bigger than 6 cm - You are in reasonably good health (able to perform basic self-care) - Your kidneys are functioning adequately - You are mentally and physically able to complete memory and thinking tests over time **You may NOT be eligible if...** - You have small cell lung cancer or germ cell tumors - You have too many or too large brain tumors for this treatment approach - You have poor kidney function - You are unwilling to complete the cognitive assessments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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