Metastatic Malignant Neoplasm in the Brain Clinical Trials

18 recruiting

Metastatic Malignant Neoplasm in the Brain Trials at a Glance

18 actively recruiting trials for metastatic malignant neoplasm in the brain are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Phase 2 with 5 trials, with the heaviest enrollment activity in Los Angeles, Tampa, and Houston. Lead sponsors running metastatic malignant neoplasm in the brain studies include M.D. Anderson Cancer Center, Mayo Clinic, and Jonsson Comprehensive Cancer Center.

Browse metastatic malignant neoplasm in the brain trials by phase

Treatments under study

About Metastatic Malignant Neoplasm in the Brain Clinical Trials

Looking for clinical trials for Metastatic Malignant Neoplasm in the Brain? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Metastatic Malignant Neoplasm in the Brain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Metastatic Malignant Neoplasm in the Brain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 118 of 18 trials

Recruiting
Phase 3

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Stage IV Lung Cancer AJCC v8Metastatic Malignant Neoplasm in the BrainMetastatic Lung Small Cell Carcinoma+1 more
NRG Oncology200 enrolled227 locationsNCT04804644
Recruiting
Phase 2

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic90 enrolled7 locationsNCT05222620
Recruiting
Phase 3

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell Carcinoma+7 more
NRG Oncology269 enrolled263 locationsNCT06500455
Recruiting

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Central Nervous System NeoplasmMetastatic Malignant Neoplasm in the BrainPrimary Brain Neoplasm+1 more
M.D. Anderson Cancer Center200 enrolled1 locationNCT04988009
Recruiting
Phase 2

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

Central Nervous System NeoplasmMetastatic Malignant Neoplasm in the BrainCranial Nerve Disorder
OHSU Knight Cancer Institute150 enrolled1 locationNCT03270059
Recruiting
Phase 4

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Malignant Neoplasm in the Brain
City of Hope Medical Center10 enrolled1 locationNCT05376878
Recruiting
Phase 2

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast CarcinomaPrognostic Stage IV Breast Cancer AJCC v8+1 more
Roswell Park Cancer Institute23 enrolled3 locationsNCT04348747
Recruiting
Not Applicable

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Metastatic Malignant Neoplasm in the BrainGlioblastomaGlioma
Mayo Clinic100 enrolled1 locationNCT04047264
Recruiting
Phase 1

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Malignant Brain NeoplasmMetastatic Malignant Neoplasm in the BrainMeningioma+1 more
Jonsson Comprehensive Cancer Center20 enrolled1 locationNCT06650163
Recruiting
Not Applicable

Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis

Malignant Brain NeoplasmMetastatic Malignant Neoplasm in the Brain
Jonsson Comprehensive Cancer Center42 enrolled1 locationNCT07339085
Recruiting
Phase 1Phase 2

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+1 more
Kari Kendra30 enrolled1 locationNCT05588453
Recruiting
Phase 3

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic140 enrolled4 locationsNCT03750227
Recruiting
Not Applicable

Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors

Metastatic Malignant Neoplasm in the BrainBrain NeoplasmRecurrent Brain Neoplasm
M.D. Anderson Cancer Center75 enrolled1 locationNCT02754544
Recruiting
Phase 3

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Recurrent Breast CarcinomaStage IV Breast Cancer AJCC v6 and v7Cardiotoxicity+2 more
SWOG Cancer Research Network491 enrolled590 locationsNCT03418961
Recruiting
Early Phase 1

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Emory University10 enrolled1 locationNCT06328686
Recruiting
Phase 3

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

Metastatic Malignant Neoplasm in the BrainMalignant Neoplasm
M.D. Anderson Cancer Center180 enrolled1 locationNCT03741673
Recruiting
Phase 2

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+4 more
SWOG Cancer Research Network112 enrolled331 locationsNCT04511013
Recruiting
Not Applicable

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University90 enrolled2 locationsNCT03184038