RecruitingNCT03193151

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation

Diagnostic and Therapeutic Applications of Microarrays in Liver Transplantation, a Multicenter Study

Sponsor

University of Alberta

Enrollment

300 participants

Start Date

Dec 19, 2017

Study Type

OBSERVATIONAL

Conditions

Liver Dysfunction

Summary

INTERLIVER is a prospective observational study of the relationship of the molecular phenotype of 300 liver transplant biopsies to the histologic phenotype and the clinical features and outcomes. A segment of a biopsy performed as standard-of-care for indications, or by center protocol, will be used for gene expression study.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

biopsy for clinical indications

Exclusion Criteria1

no consent, pregnant women

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Interventions

PROCEDUREliver biopsy

5 mm fragment of liver transplant biopsy taken for clinical indication

Locations(15)

University of California San Francisco, Transplant Research Unit

San Francisco, California, United States

Northwestern Memorial Hospital

Chicago, Illinois, United States

University of Maryland School of Medicine

Baltimore, Maryland, United States

Henry Ford Transplant Institute

Detroit, Michigan, United States

Vanderbilt University Medical Center, Vanderbilt Transplant Center

Nashville, Tennessee, United States

Baylor University Medical Center, Annette C. and Harold C. Simmons Transplant Institute

Dallas, Texas, United States

Transplant Surgery, VCU Medical Center

Richmond, Virginia, United States

Division of Transplant Surgery, University of Washington

Seattle, Washington, United States

Centenary Institute of Cancer Medicine & Cell Biology, Royal Prince Alfred Hospital

Camperdown, Australia

University of Alberta, Laboratory Medicine and Pathology

Edmonton, Alberta, Canada

Dep. of Nephrology, Transplantation & Internal Med., Samodzielny Publiczny Szpital Kliniczny im. A. Mieleckiego

Katowice, Poland

Independent Public Composite Regional Hospital

Szczecin, Poland

Warsaw Medical University, Jesus the Child Clinical Hospital

Warsaw, Poland

Warsaw Medical University, Independent Public Clinical Hospital

Warsaw, Poland

Institute for Liver Science, King's College London

London, United Kingdom

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