IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2

This study is testing whether two treatments — IVIG (an infusion of antibodies from donated blood) and rituximab (a drug that depletes certain immune cells) — can help people with psychosis caused by their own immune system attacking the brain, a condition called antibody-associated or autoimmune psychosis. **You may be eligible if...** - You have had an episode of psychosis (hallucinations, delusions, or severely disorganised thinking) lasting more than 2 weeks - Blood or spinal fluid tests show specific abnormal antibodies attacking the brain (such as NMDAR or LGI1 antibodies) - Your symptoms meet a specific severity threshold on a psychiatric rating scale - This may be a first episode or a relapse after at least 6 months of remission **You may NOT be eligible if...** - Your current episode of psychosis has lasted more than 24 months - You have another severe neurological disease - You have signs of acute brain inflammation (encephalopathy) - You have active hepatitis B infection or serious liver disease Talk to your doctor to see if this trial is right for you.