Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

This study uses brain imaging (MRI) to investigate why social isolation and loneliness are so common and harmful in people with serious mental illnesses such as schizophrenia or bipolar disorder, to help develop better treatments. **You may be eligible if...** - You are between 18 and 55 years old - You have been diagnosed with a psychotic disorder (such as schizophrenia or schizoaffective disorder) or a mood disorder (such as bipolar disorder or major depression) - You are proficient in English **You may NOT be eligible if...** - You have a neurological disorder (such as epilepsy or brain injury) - You have a current substance use disorder (within the past 6 months) - Your medication has recently changed or you are having a major symptom flare-up - You have metal implants, claustrophobia, or other reasons you cannot safely have an MRI Talk to your doctor to see if this trial is right for you.