RecruitingNCT03250078

A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals


Sponsor

Nuvance Health

Enrollment

200 participants

Start Date

Nov 1, 2016

Study Type

OBSERVATIONAL

Conditions

Summary

The main goal of this study is to screen and detect pancreatic cancer and precursor lesions in individuals with a strong family history or genetic predisposition to pancreatic cancer. Magnetic Resonance Imaging and Magnetic cholangiopancreatography (MRI/MRCP) will be utilized to screen for early stage pancreatic cancer or precursor lesions. Participants will be asked to donate a blood sample at specific intervals for the creation of a bio-bank necessary for the development of a blood based screening test for Pancreatic Cancer.


Eligibility

Min Age: 50 YearsMax Age: 90 Years

Plain Language Summary

Simplified for easier understanding

This study is offering regular screening (using MRI scans) to people at high hereditary risk for pancreatic cancer, in order to catch it as early as possible. **You may be eligible if...** - You have two or more first-degree relatives (parent, sibling, or child) with pancreatic cancer - OR you carry a known high-risk gene mutation (such as BRCA1, BRCA2, Lynch syndrome, ATM, PALB2, or CDKN2A) AND have at least one close relative with pancreatic cancer - You are at least 50 years old, or at least 10 years younger than the youngest relative diagnosed with pancreatic cancer - You are in good general health and able to undergo MRI scans **You may NOT be eligible if...** - You have already been diagnosed with pancreatic cancer - You have had another cancer requiring chemotherapy within the last 5 years - You have hereditary pancreatitis - You have poor kidney function or a contraindication to MRI or contrast dye - You are pregnant or nursing Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMRI/MRCP

An MRI/MRCP plus IV gadolinium contrast with high resolution imaging of the pancreas will be performed annually


Locations(1)

Nuvance Health

Norwalk, Connecticut, United States

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NCT03250078


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