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RecruitingNCT03250091

Surveillance of Patients With Precancerous Lesions of the Stomach

Surveillance Strategies of Patients With Precancerous Conditions and Lesions in the Stomach

Sponsor

University of Latvia

Enrollment

2,000 participants

Start Date

Jun 19, 2017

Study Type

OBSERVATIONAL

Conditions

Gastric CancerGastric DysplasiaGastric Intestinal MetaplasiaGastric Atrophy

Summary

The project will aim to identify and determine subgroups of patients with different risks of progression to gastric cancer and to assess appropriate follow-up intervals. Implementing risk stratification only high risk individuals will be offered and performed endoscopic surveillance.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is following patients who have pre-cancerous changes in the stomach lining to better understand how these conditions progress over time and how they should be monitored. **You may be eligible if...** - You are already scheduled for or undergoing an upper endoscopy (a camera scope down the throat to examine the stomach) - You are motivated to participate and willing to sign a consent form **You may NOT be eligible if...** - You already have a confirmed diagnosis of stomach (gastric) cancer - You are unable or unwilling to cooperate with follow-up visits Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREUpper endoscopy with biopsies

Upper endoscopy with proper biopsy work-up will be used for identification and stratification of gastric lesions as well as acquisition of biopsies for histopathological examination, including H.pylori detection

PROCEDUREPlasma/serum sampling

Plasma/serum sampling will be used to obtain information for group stratification, e.g. H.pylori status determination, serum biomarkers

PROCEDUREBiopsies for gastric microbiota

During upper endoscopy biopsies for gastric microbiota analysis will be obtained

PROCEDUREFaecal sample acquisition

Faecal samples will be obtained for faecal occult blood testing as well as microbiota analysis

Locations(1)

University of Latvia

Riga, Latvia

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