Adjuvant Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) in Resected High Risk Colon Cancer Patients

This study is testing a new technique called PIPAC (Pressurized IntraPeritoneal Aerosol Chemotherapy) — where chemotherapy is sprayed as a fine mist into the abdominal cavity through a minimally invasive procedure — as a preventive treatment after surgery in colon cancer patients at high risk of the cancer returning in the belly lining. **You may be eligible if...** - You have had surgery to fully remove your colon cancer, and your tumor was high-risk: either it perforated (ruptured) or invaded through the bowel wall (T4) or had limited spread to the lining of the abdomen or ovaries (which was also removed) - You are in good overall health (performance status 0–1) and over 18 - You have adequate kidney, liver, and blood function **You may NOT be eligible if...** - Imaging or clinical exams show the cancer has come back - You have previously had a type of heated abdominal chemotherapy wash surgery (HIPEC) - You have had another cancer diagnosis within the last 2 years - You have an allergy to oxaliplatin (platinum-based chemotherapy) - You have poor kidney, heart, or liver function - You have conditions that make laparoscopy (minimally invasive surgery) unsafe, like severe abdominal scarring Talk to your doctor to see if this trial is right for you.