ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

This study is developing a specialized treatment protocol for children and young adults with Down syndrome who have been newly diagnosed with a type of blood cancer called acute lymphoblastic leukemia (ALL), recognizing that people with Down syndrome may respond to cancer treatments differently than others. **You may be eligible if...** - You have Down syndrome (diagnosed clinically or genetically, including mosaic Down syndrome) - You have been newly diagnosed with ALL (acute lymphoblastic leukemia) - You are under 21 years old at the time of enrollment - You are in reasonably good overall health **You may NOT be eligible if...** - You have a second cancer - Your leukemia tests positive for the Philadelphia chromosome (a specific genetic change) or is a certain rare subtype (mature B-cell ALL or mixed phenotype) - You have previously received cancer chemotherapy (short-term steroids for less than 7 days are allowed) - You have severely impaired kidney or liver function - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.