RecruitingNCT03291652

Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential

Sponsor

Chinese University of Hong Kong

Enrollment

140 participants

Start Date

Feb 1, 2010

Study Type

OBSERVATIONAL

Conditions

Ischemic Stroke Atheroscleroses, Cerebral

Summary

The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).

Eligibility

Min Age: 30 YearsMax Age: 85 Years

Inclusion Criteria9

Patient is 30 to 85 years of age, inclusive.
Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD.
Patient who has no contra-indication for the proposed imaging tests.
Patient understands the purpose and requirements of the study, and has provided an informed consent.
Patient is 30 to 85 years of age, inclusive.
Patient who has a high-grade (\>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence.
Patient has no MES detected on TCD examination.
Patient who has no contra-indication for the proposed imaging tests.
Patient understands the purpose and requirements of the study, and has provided an informed consent.

Exclusion Criteria5

Subject who meets one or more of the following criteria cannot be recruited in the study:
Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc.
A tandem stenosis \>50% at proximal internal carotid artery.
Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
A medical condition that would not allow the patient to adhere to the protocol or complete the study.

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Interventions

DIAGNOSTIC_TESTDSA/3DRA

DSA/3DRA

Locations(1)

Chinese University of Hong Kong

Hong Kong, Hong Kong

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