Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

This study is tracking women who carry BRCA1 or BRCA2 gene mutations — genes linked to higher risk of ovarian and breast cancer — to better understand their health outcomes over time. **You may be eligible if...** - You are a woman with a BRCA1 or BRCA2 gene mutation (or both), or an uncertain gene change called a variant of uncertain significance (VUS) - You have already received genetic counseling at a medical facility - You are 20 years old or older - You are willing to give written consent to participate **You may NOT be eligible if...** - You currently have ovarian or fallopian tube cancer - You have a past diagnosis of ovarian, fallopian tube, or peritoneal (abdominal lining) cancer - The study doctor decides participation is not appropriate for you Talk to your doctor to see if this trial is right for you.