RecruitingNot ApplicableNCT03312556

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure

Sponsor

Vanderbilt University Medical Center

Enrollment

12 participants

Start Date

Sep 21, 2017

Study Type

INTERVENTIONAL

Conditions

Autonomic Failure Supine Hypertension

Summary

Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria1

Patients with autonomic failure and with supine hypertension from all races

Exclusion Criteria4

All medical students
Pregnant women
High-risk patients (e.g. heart failure, symptomatic coronary artery disease, liver impairment, history of stroke or myocardial infarction)
History of serious allergies or asthma.

Interventions

DEVICEcontinuous positive airway pressure (CPAP)

Continuous positive airway pressure(CPAP) will be applied during the night starting from 20:00. CPAP level will be determined during an acute CPAP trial.

DRUGPlacebo

Placebo pill or patch. Single dose