RecruitingNot ApplicableNCT03312556

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Treatment of Supine Hypertension in Autonomic Failure With Continuous Positive Airway Pressure


Sponsor

Vanderbilt University Medical Center

Enrollment

12 participants

Start Date

Sep 21, 2017

Study Type

INTERVENTIONAL

Conditions

Summary

Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. The purpose of this study is to assess whether continuous positive airway pressure (CPAP) decreases blood pressure in autonomic failure patients with supine hypertension.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether CPAP (a breathing machine commonly used for sleep apnea) can reduce dangerously high blood pressure that some people with autonomic failure — a nerve condition that disrupts automatic body functions — experience when lying flat on their back. **You may be eligible if...** - You have been diagnosed with autonomic failure - You have high blood pressure when lying on your back (supine hypertension) - You are willing to participate regardless of race or background **You may NOT be eligible if...** - You are a medical student - You are pregnant - You have heart failure, serious coronary artery disease, liver problems, or a history of stroke or heart attack Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEcontinuous positive airway pressure (CPAP)

Continuous positive airway pressure(CPAP) will be applied during the night starting from 20:00. CPAP level will be determined during an acute CPAP trial.

DRUGPlacebo

Placebo pill or patch. Single dose


Locations(1)

Autonomic Dysfunction Center/ Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT03312556


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