Autonomic Failure Clinical Trials

11 recruiting

Autonomic Failure Trials at a Glance

12 actively recruiting trials for autonomic failure are listed on ClinicalTrialsFinder across 6 cities in 5 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Nashville, Bilbao, and Boston. Lead sponsors running autonomic failure studies include Vanderbilt University Medical Center, Daniel Claassen, and NYU Langone Health.

Browse autonomic failure trials by phase

Treatments under study

About Autonomic Failure Clinical Trials

Looking for clinical trials for Autonomic Failure? There are currently 11 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Autonomic Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Autonomic Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Not Applicable

CPAP for the Treatment of Supine Hypertension

Multiple System AtrophyParkinson DiseaseAutonomic Failure+3 more
Vanderbilt University Medical Center59 enrolled1 locationNCT05489575
Recruiting
Phase 1

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+2 more
Daniel Claassen40 enrolled1 locationNCT04246437
Recruiting
Not Applicable

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

HypertensionMultiple System AtrophyAutonomic Failure+1 more
Vanderbilt University Medical Center20 enrolled1 locationNCT03042988
Recruiting
Phase 1

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center29 enrolled1 locationNCT02429557
Recruiting
Early Phase 1

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center31 enrolled1 locationNCT04620382
Recruiting
Phase 1Phase 2

Automated Abdominal Binder for Orthostatic Hypotension

Multiple System AtrophyAutonomic FailurePure Autonomic Failure+1 more
Vanderbilt University Medical Center31 enrolled1 locationNCT03482297
Recruiting
Not Applicable

Treatment of Supine Hypertension in Autonomic Failure (CPAP)

Autonomic FailureSupine Hypertension
Vanderbilt University Medical Center12 enrolled1 locationNCT03312556
Recruiting
Not Applicable

Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Autonomic FailureSupine Hypertension
Vanderbilt University Medical Center44 enrolled1 locationNCT04502225
Recruiting
Phase 1

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center34 enrolled1 locationNCT02897063
Recruiting
Not Applicable

Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms

Multiple System AtrophyAutonomic FailurePure Autonomic Failure+2 more
Vanderbilt University Medical Center29 enrolled1 locationNCT04782830
Recruiting

Natural History Study of Synucleinopathies

Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+5 more
NYU Langone Health800 enrolled8 locationsNCT01799915
Recruiting
Not Applicable

CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study

Autonomic FailureNeurogenic Orthostatic Hypotension
University of Calgary28 enrolled1 locationNCT05908760