RecruitingNCT03334708

A Study of Blood Based Biomarkers for Pancreas Adenocarcinoma

Development of Biomarkers for the Early Detection, Surveillance and Monitoring of Pancreatic Ductal Adenocarcinoma


Sponsor

Memorial Sloan Kettering Cancer Center

Enrollment

700 participants

Start Date

Oct 30, 2017

Study Type

OBSERVATIONAL

Conditions

Summary

The purpose of this study is to develop a minimally invasive test to diagnose pancreatic cancer at early stages of disease and monitor response to treatment.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood samples from patients with pancreatic cancer — both those with advanced disease receiving treatment and those in earlier stages — to find blood-based biological markers that may help detect the cancer earlier and monitor how well treatment is working. **You may be eligible if...** - You are 18 or older - You have been diagnosed with locally advanced or metastatic pancreatic adenocarcinoma, OR you have pancreatic cancer in an earlier stage - You are planning to receive or currently receiving treatment - Your blood count (hemoglobin) is above 8 - You are well enough to participate (ECOG performance status 0–2) **You may NOT be eligible if...** - Your diagnosis has not been confirmed - You are not able to provide blood or tissue samples - Your general health does not meet the study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTBlood Draw

If clinically safe, up to approximately 50ml of blood will be drawn, not to exceed the following criteria: Patients and controls weighing 50kg or more * For draw amounts up to 50mL, there is no required hemoglobin threshold. * For amounts exceeding 50mL, patients who meet standard blood banking criteria (e.g., hemoglobin values within normal limits and minimum weight of 50kg) may give as much as a full unit of blood (500mL) at one time or in divided fractions over a 56 day/eight week period. Patients and controls weighing \< 50kg * For patients whose hemoglobin is below normal limits but at least 7.0 gm/dL, no more than a total of 50 ml of blood or 5 ml/kg, whichever is less, may be collected per 56 day/eight week period, but no more than approximately 2 ml/kg of blood at any one time.

DIAGNOSTIC_TESTTumor Tissue Collection

Tumor tissue will be obtained by already planned biopsy, either at Memorial Sloan Kettering Cancer Center or elsewhere

DIAGNOSTIC_TESTCyst Fluid

Cyst fluid will be obtained by already planned biopsy, either at Memorial Sloan Kettering Cancer Center or elsewhere


Locations(13)

Memorial Sloan Kettering Monmouth (All protocol activities)

Middletown, New Jersey, United States

Memorial Sloan Kettering Bergen (All protocol activities)

Montvale, New Jersey, United States

Cold Springs Harbor Laboratory (Specimen Analysis)

Cold Spring Harbor, New York, United States

Memorial Sloan Kettering Cancer Center @ Commack (All Protocol Activities)

Commack, New York, United States

Memorial Sloan Kettering Westchester (All protocol activities)

Harrison, New York, United States

New York University

New York, New York, United States

Memorial Sloan - Kettering Cancer Center

New York, New York, United States

Memorial Sloan Kettering Basking Ridge (All protocol activities)

New York, New York, United States

Weill Cornell Medical Center

New York, New York, United States

Memorial Sloan Kettering Nassau (All protocol activities)

Rockville Centre, New York, United States

Sha'are Zedek Medical Center

Jerusalem, Israel

Weizmann Institute of Science

Rehovot, Israel

Sheba Medical Center

Tel Litwinsky, Israel

View Full Details on ClinicalTrials.gov

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NCT03334708


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