Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane

Exclusion Criteria14

• Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation
• History of difficult intubation or ventilation
• Airway malformation
• Congenital heart disease
• Cardiac arrhythmias
• Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder
• History of or family history of malignant hyperthermia
• Electrolyte disorders
• Gastrointestinal disease
• Hepatic dysfunction
• Renal dysfunction
• Metabolic disease, such as diabetes
• Obesity, defined as a body mass index greater than the 95% percentile for age
• Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.