RecruitingPhase 4NCT03384563

Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane


Sponsor

Baylor College of Medicine

Enrollment

180 participants

Start Date

Feb 18, 2018

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in children between the age ranges of: 1-6 months; 6-12 months of age and 12 months-36 months years of age.


Eligibility

Min Age: 1 MonthMax Age: 36 Months

Plain Language Summary

Simplified for easier understanding

This pediatric anesthesia study is measuring how much the sedative drug dexmedetomidine reduces the required dose of sevoflurane (an inhaled anesthetic gas) in young children having surgery. Understanding this interaction helps anesthesiologists use lower doses of gas anesthetic, which may reduce side effects and help children wake up more comfortably after surgery. You may be eligible if: - Your child is between 1 month and 3 years old - Your child is scheduled for a surgical procedure You may NOT be eligible if: - Your child has interstitial lung disease, chest wall disease, or bronchospastic disease with recent flare-ups - Your child has a history of difficult intubation or airway malformation - Your child has congenital heart disease or cardiac arrhythmias - Your child has a neurological condition such as developmental delay, cerebral palsy, or seizure disorder - Your child or a family member has a history of malignant hyperthermia - Your child has electrolyte disorders, gastrointestinal disease, liver or kidney dysfunction, or diabetes - Your child is obese (above the 95th percentile BMI for age) - Your child was born prematurely (before 37 weeks) - Your child takes medications that may affect anesthetic requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexmedetomidine

Dexmedetomidine 9 arms


Locations(1)

Texas Children's Hospital

Houston, Texas, United States

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NCT03384563


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