RecruitingNCT03386981

Metabolic Profile of Bone in Professional Athletes

Study of the Metabolic Profile of Bone in Professional Athletes as a Function of the Kind of Physical Activity Performed

Sponsor

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Enrollment

200 participants

Start Date

Feb 4, 2016

Study Type

OBSERVATIONAL

Conditions

Physical Activity Bone Disease, Metabolic

Summary

Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the production of several mediators and effectors that have systemic effects). However, different kinds of physical activity exert different effects on bone and endocrine system. Aim of the study is to investigate the effects of different kinds of physical activity on bone metabolism and on the relationships existing between bone metabolism, energy metabolism, hormone profile, and organ functionality.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

>/= 18 yo
healthy status
caucasians

Exclusion Criteria10

< 18 yo
pregnancy status
ongoing or previous (<5 years) neoplasia
acute or chronic inflammatory pathologies
primary metabolic diseases of bone
recent bone fractures (< 6 months)
chronic drugs
recent drugs administration (< 2 months) for non steroidal anti-inflammatory drugs (NSAIDs) and steroids
anxious-depressive conditions
inability to understand the information given by the recruiting physician

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERblood and saliva tests

Blood and saliva will be tested for: bone turnover markers, cytokines, chemokines, adipokines, myokines and hormones regulating bone and energy metabolism