RecruitingNCT03387865

A Clinico-biological Database of Lung Cancers

Sponsor

University Hospital, Lille

Enrollment

500 participants

Start Date

Mar 13, 2019

Study Type

OBSERVATIONAL

Conditions

Lung Cancer

Summary

This prospective, single-center, interventional study is conducted in order to achieve a biological bank accompanied by clinical data. Blood samples, optional tumor tissue and fecal samples are collected, processed and banked for all the included subjects. Those samples are collected before the start of treatment, at the time of first tumor assessment, at the time of first and second disease progression. The subjects are treated according to standard of care. Clinical data are collected at each sampling time. The primary objective of the study is to identify biological, clinical and tumoral factors associated with tumor response according SOC treatment.

Eligibility

Plain Language Summary

Simplified for easier understanding

This trial is building a large clinical and biological database of patients newly diagnosed with lung cancer, collecting tissue samples, blood, and detailed treatment and outcome information over time, to help researchers better understand the disease and develop more effective future treatments. **You may be eligible if...** - You have been newly diagnosed with lung cancer (confirmed by tissue or cell testing) or have a lung tumor suspected to be cancer requiring treatment - You are about to begin your first treatment for lung cancer (surgery, chemotherapy, radiation, or targeted therapy) - You are 18 years or older - You have at least one measurable or assessable tumor area - You are enrolled in a social security scheme (France) - You are able to follow study procedures **You may NOT be eligible if...** - You have already started cancer treatment before enrolling - You are unable to participate due to health or other reasons - You do not have a confirmed or strongly suspected lung cancer diagnosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREtissue biopsies

additional biopsies will be performed during a diagnostic or therapeutic procedure, in order to sample tumor tissue and healthy tissue.

PROCEDUREblood sampling

additional blood samples will be collected during a SOC sampling procedure (2 EDTA 7.5 ml tubes, 2 SST 7.5 ml tubes and 2 citrate 5 ml tubes)

GENETICDNA banking

constitutional and somatic genetic alterations will be analysed for subjects who consent, from either tumor or healthy tissue, or whole blood buffy coat after centrifugation