Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation

This trial is testing whether a supervised exercise training program can improve heart pumping efficiency and quality of life in patients who have persistent or permanent atrial fibrillation — a chronic irregular heartbeat that has not returned to normal on its own. **You may be eligible if...** - You have persistent or permanent atrial fibrillation - Your heart rate at rest is controlled (100 beats per minute or fewer) - You are able to perform a supervised exercise test - You are 40 years old or older **You may NOT be eligible if...** - You already do regular exercise training more than twice per week - You have unstable chest pain (unstable angina) - You have been diagnosed with severe narrowing of the mitral or aortic heart valves - You have a thickened heart muscle causing significant obstruction of blood flow (hypertrophic obstructive cardiomyopathy) - You are pregnant, breastfeeding, or planning to become pregnant during the study Talk to your doctor to see if this trial is right for you.