Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation - a Multi-centre Randomized Controlled Trial
Ottawa Heart Institute Research Corporation
132 participants
Jan 23, 2019
INTERVENTIONAL
Conditions
Summary
The main purpose of this project is to evaluate the effects of high-intensity interval training (HIIT) compared to moderate-intensity continuous exercise training (MICE) and standard care on exercise capacity and quality of life in patients with persistent or permanent atrial fibrillation. Positive findings are vitally important for these patients, given the condition's substantial morbidity, mortality and high economic costs.
Eligibility
Inclusion Criteria4
- persistent or permanent atrial fibrillation;
- rate controlled with a resting ventricular rate of equal to or less than 100 bpm;
- able to perform a symptom-limited exercise test;
- at least 40 years of age (i.e. participants must be 40 years or older);
Exclusion Criteria7
- currently participating in routine exercise training (more than two times per week);
- unstable angina;
- diagnosed severe mitral or aortic stenosis;
- diagnosed hypertrophic obstructive cardiomyopathy with significant obstruction;
- pregnant, lactating or planning to become pregnant during the study period;
- unable to provide written, informed consent, or
- unwilling or unable to return for follow up at week 12.
Interventions
Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks.
Participants will attend on-site high-intensity interval training two times weekly for 12 weeks.
Locations(2)
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NCT03397602