Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome

This trial is studying how the hormone estrogen affects the brain's control of reproductive hormones in women with polycystic ovary syndrome (PCOS) — a hormonal condition that can cause irregular periods, excess body hair, and fertility problems — compared to women without the condition, to better understand the hormonal imbalances involved. **You may be eligible if...** - You are a post-pubertal woman aged 18 to 30 years (more than 4 years since your first period) - PCOS group: You have PCOS with signs of excess male hormones (such as unwanted hair growth or elevated testosterone) and irregular periods (fewer than 9 per year), without another identified cause - Control group: You have regular menstrual cycles (every 26 to 35 days) and no signs of excess male hormones **You may NOT be eligible if...** - You are outside the 18 to 30 age range - Your irregular periods or hormonal issues are caused by something other than PCOS - You are taking hormonal medications or have health conditions that could affect hormone levels - You are pregnant or planning to become pregnant during the study Talk to your doctor to see if this trial is right for you.