Pathophysiology of Inborn Immunodeficiencies
Pathophysiologie Angeborener Immundefekte
University of Zurich
300 participants
Mar 1, 2015
OBSERVATIONAL
Conditions
Summary
The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and/or a deregulated inflammatory response, is poorly understood. Available treatments are often not specific for a distinct target and might be associated with side effects. To elucidate pathophysiology of different PIDs, stool, urine, blood, tissue biopsies and/or bone marrow will be collected and analysed for anti-microbial activity and inflammatory response. In a second step, targeted treatment for different PIDs might be developed preclinically and ex vivo according to underlying pathophysiology.
Eligibility
Inclusion Criteria2
- Clinical diagnosis of an inborn error of immunity (primary immunodeficiency, PID)
- Clinically healthy (non-age matched) volunteer
Exclusion Criteria3
- exclusion of an inborn error of immunity
- secondary immunodeficiency
- refusal to enter the study
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Interventions
Characterisation of cellular and functional phenotype in different PIDs
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03422614