Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

This study tests a treatment using specially engineered immune cells (cytotoxic T-lymphocytes) to fight adenovirus infections that have not responded to standard antiviral medications. It targets patients who received a stem cell or organ transplant and are now fighting a resistant adenovirus infection. You may be eligible if: - You have an adenovirus infection after a stem cell transplant, organ transplant, or due to a primary immune deficiency - The virus is not responding to at least two weeks of antiviral treatment, or you cannot tolerate the antiviral medications - You are between 1 month and 79 years old - A suitable immune cell donor is available - Female patients of childbearing age must have a negative pregnancy test You may NOT be eligible if: - You have severe graft-versus-host disease (grade 2 or higher) - You are currently taking high-dose steroids (more than 0.5 mg/kg prednisone) - You have received a donor lymphocyte infusion within the past 4 weeks - You have a very low performance status (Karnofsky/Lansky score 30% or below) - You are pregnant, breastfeeding, or not using effective contraception - You are known to be HIV positive - You have known human anti-mouse antibodies Talk to your doctor to see if this trial is right for you.