Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy

This study is using advanced imaging tests to better understand how bone marrow changes in patients with leukemia (AML or ALL) who are receiving total body irradiation (whole-body radiation) as part of a stem cell transplant preparation — with the goal of improving future treatment planning. **You may be eligible if...** - You have been diagnosed with acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) - You are already enrolled in a related treatment trial at City of Hope involving specialized radiation therapy - You are willing to participate in optional imaging scans (depending on the study group) **You may NOT be eligible if...** - You are not enrolled in the qualifying related treatment trials - You do not meet the eligibility criteria for those underlying trials - You are not in first or second remission (for the standard radiation group) Talk to your doctor to see if this trial is right for you.