RecruitingNCT03435237

Phenotyping Asthma for Bronchial Thermoplasty

Phenotyping Asthma for Bronchial Thermoplasty: Airway Smooth Muscle Structure and Function

Sponsor

Massachusetts General Hospital

Enrollment

50 participants

Start Date

May 10, 2021

Study Type

OBSERVATIONAL

Conditions

Severe Asthma

Summary

This study will evaluate a new imaging technology, called optical coherence tomography (OCT) to examine the asthmatic airways before and after bronchial thermoplasty, which is a new treatment option for severe asthmatic patients. The aim of this study is to learn more about how airways respond to this new treatment. In the future the investigators hope OCT will aid clinicians in the initial assessment, management and long-term follow up of patients receiving bronchial thermoplasty.

Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is examining the characteristics and biology of patients with severe asthma who are undergoing a procedure called bronchial thermoplasty — a treatment that uses controlled heat to reduce the amount of muscle in the airways — to better understand who benefits most. **You may be eligible if...** - You are between 18 and 60 years old - You are already scheduled to receive bronchial thermoplasty for asthma - You are a non-smoker or have less than 5 pack-years of tobacco use - You have no other lung diseases - Your asthma has been confirmed by breathing tests showing the typical reversible airway obstruction - If you are a woman of childbearing age, you have a negative pregnancy test **You may NOT be eligible if...** - You smoke or have significant tobacco history - You have other lung conditions - You are pregnant or trying to become pregnant - You do not meet the standard criteria for an asthma diagnosis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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