Severe Asthma Clinical Trials

25 recruiting

Severe Asthma Trials at a Glance

27 actively recruiting trials for severe asthma are listed on ClinicalTrialsFinder across 6 cities in 22 countries. The largest study group is Phase 3 with 5 trials, with the heaviest enrollment activity in Miami, Tampa, and Flint. Lead sponsors running severe asthma studies include AstraZeneca, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), and Generate Biomedicines.

Browse severe asthma trials by phase

Treatments under study

About Severe Asthma Clinical Trials

Looking for clinical trials for Severe Asthma? There are currently 25 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Severe Asthma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Severe Asthma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 27 trials

Recruiting

International Severe Asthma Registry: Canadian Cohort

Severe Asthma
University of British Columbia714 enrolled12 locationsNCT04045587
Recruiting
Phase 3

A Phase III Study of CM326 in Subjects With Moderate to Severe Asthma

Moderate to Severe Asthma
CSPC Baike (Shandong) Biopharmaceutical Co., Ltd.230 enrolled1 locationNCT07372287
Recruiting

Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma

Severe Asthma
University of Kansas Medical Center5 enrolled1 locationNCT06985225
Recruiting
Phase 3

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

Severe Asthma
Generate Biomedicines786 enrolled27 locationsNCT07276724
Recruiting

Severe Asthma Network Italy

Severe Asthma
Società Italiana di Allergologia, Asma e Immunologia Clinica5,000 enrolled1 locationNCT06625216
Recruiting
Phase 3

Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab

Severe Asthma
AstraZeneca400 enrolled76 locationsNCT07363642
Recruiting

Real-World Effectiveness of Benralizumab in Allergic Bronchopulmonary Aspergillosis

Allergic Bronchopulmonary AspergillosisSevere AsthmaABPA
Qianfoshan Hospital20 enrolled2 locationsNCT07530770
Recruiting

Remission in Adults With Severe Asthma in Thailand

Severe AsthmaAsthma Control Level
Thammasat University230 enrolled1 locationNCT07328035
Recruiting
Phase 2

A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma

Moderate to Severe Asthma
Incyte Corporation240 enrolled83 locationsNCT05851443
Recruiting
Phase 3

A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)

Severe Asthma
Generate Biomedicines786 enrolled11 locationsNCT07359846
Recruiting

Clinical and demOgRaphic Features of Patients With Uncontrolled Severe Asthma in Russia (CORSAR)

Severe Asthma
AstraZeneca5,000 enrolled37 locationsNCT06472310
Recruiting
Phase 2

A Long-Term Safety and Efficacy Study of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALOUR)

Severe Asthma
Upstream Bio Inc.436 enrolled84 locationsNCT06966479
Recruiting
Phase 4

CHEST: A Collaboration With Community HEalth Centers to Implement SmarT for Asthma

Moderate to Severe Asthma
Washington University School of Medicine2,000 enrolled7 locationsNCT07241117
Recruiting
Not Applicable

Bronchial Thermoplasty for Adults With Severe Asthma in the Biologic Era

Severe AsthmaAsthma ExacerbationsBronchial Thermoplasty
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)90 enrolled2 locationsNCT07292805
Recruiting
Phase 2

Evaluate the Efficacy and Safety of FB704A in Adult With Severe Asthma

Severe Asthma
Oneness Biotech Co., Ltd.20 enrolled9 locationsNCT05018299
Recruiting

Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

Severe Asthma
Bastiaan Driehuys5 enrolled1 locationNCT07139899
Recruiting

Experience of Biologic Treatments for Severe Asthma: a Survey

Severe Asthma
Royal Devon and Exeter NHS Foundation Trust400 enrolled1 locationNCT06903780
Recruiting
Not Applicable

Early High-flow Oxygen Therapy With nebuLized Beta-2-agonist Using a Vibrating Mesh for the Management of Moderate to Severe Asthma Exacerbation in the Emergency Department

Moderate Asthma ExacerbationSevere Asthma Exacerbation
Poitiers University Hospital60 enrolled1 locationNCT05691218
Recruiting

Swiss Severe Asthma Register

Severe Asthma
Prof. Dr. Jörg Leuppi600 enrolled10 locationsNCT03984253
Recruiting

Exploring the Lived Experience of Young Adults With Severe Asthma

AsthmaSevere AsthmaUncontrolled Asthma
Manchester University NHS Foundation Trust46 enrolled1 locationNCT06681545