RecruitingPhase 3NCT07363642

Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab

TAPER: A Prospective, Interventional, Multicentre, Single-Arm, Phase 3b Study to Evaluate the Step-Down of Maintenance Therapy in Patients With Severe Asthma Treated With Tezepelumab

Sponsor

AstraZeneca

Enrollment

400 participants

Start Date

Jan 28, 2026

Study Type

INTERVENTIONAL

Conditions

Severe Asthma

Summary

This study aims to explore the potential for Tezepelumab-treated severe asthmatic patients to effectively and safely reduce their background maintenance medication while maintaining asthma symptom control.

Eligibility

Min Age: 12 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a medication called tezepelumab — a biologic injection that targets a protein called TSLP involved in airway inflammation — in patients with severe asthma who continue to have frequent flare-ups despite using standard treatments. **You may be eligible if...** - You are between 12 and 80 years old - You have a documented history of physician-diagnosed severe asthma - You have been on high-dose inhaled steroids plus another controller medication for at least 12 months - You have had two or more asthma attacks in the past year, or your asthma is not controlled **You may NOT be eligible if...** - You have a serious lung disease other than asthma - You have a history of anaphylaxis to biologic medications - You currently smoke or have smoked heavily in the past - You have an active parasitic infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGTezepelumab

Severe asthma taking medium-high dose ICS/LABA with up to one additional controller will be enrolled into this single arm treatment

Locations(76)

Research Site

Beijing, China

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Beijing, China

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Beijing, China

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Beijing, China

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Beijing, China

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Beijing, China

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Beijing, China

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Binzhou, China

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Changsha, China

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Changsha, China

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Chengdu, China

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Chengdu, China

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Chengdu, China

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Chengdu, China

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Chongqing, China

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Chongqing, China

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Deyang, China

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Fuzhou, China

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Guangzhou, China

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Guangzhou, China

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Guangzhou, China

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Guangzhou, China

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Guangzhou, China

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Guangzhou, China

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Guangzhou, China

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Guiyang, China

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Hangzhou, China

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Hangzhou, China

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Hangzhou, China

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Hefei, China

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Hefei, China

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Hohhot, China

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Jiangmen, China

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Jinan, China

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Jinan, China

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Jinan, China

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Jining, China

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Kunming, China

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Leshan, China

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Linyi, China

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Luzhou, China

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Meizhou, China

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Mianyang, China

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Nanchang, China

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Nanjing, China

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Nanjing, China

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Nanning, China

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Ningbo, China

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Quanzhou, China

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Shanghai, China

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Shanghai, China

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Shanghai, China

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Shanghai, China

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Shanghai, China

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Shanghai, China

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Shantou, China

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Shenyang, China

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Shenzhen, China

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Shenzhen, China

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Shijiazhuang, China

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Suining Shi, China

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Suzhou, China

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Taiyuan, China

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Taiyuan, China

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Tianjin, China

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Weifang, China

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Wenzhou, China

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Wuhan, China

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Wuhan, China

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Wuxi, China

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Xi'an, China

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Zhangzhou, China

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Zhanjiang, China

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Zhengzhou, China

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Zhengzhou, China

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Zhongshan, China

View Full Details on ClinicalTrials.gov

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NCT07363642

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