DBS for Depression

This trial is testing deep brain stimulation (DBS) — a procedure where a small device is implanted to send electrical signals to specific areas of the brain — as a treatment for severe, treatment-resistant depression that has not responded to many other therapies. **You may be eligible if...** - You are between 22 and 70 years old and not pregnant - You have been diagnosed with major depressive disorder (MDD) as your primary condition - Your current depressive episode has lasted at least 24 months, or you have had at least 2 lifetime episodes including one lasting over 12 months - You have tried and failed multiple treatments including medications, psychotherapy, and electroconvulsive therapy (ECT) - You are otherwise medically healthy enough for surgery **You may NOT be eligible if...** - You have bipolar disorder, schizophrenia, or active substance abuse - You have a serious neurological condition or brain abnormalities - You have an unstable medical condition that would make surgery risky - You are unable to provide informed consent - You have a pacemaker or other implanted device that would conflict with DBS Talk to your doctor to see if this trial is right for you.