Biobank for Cholestatic Liver Diseases.

This study is building a biobank — a library of biological samples and health data — from patients with rare liver diseases that cause bile to build up in the liver (cholestatic liver diseases), including primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), to help researchers find better treatments. **You may be eligible if...** - You have been diagnosed with PSC (primary sclerosing cholangitis) and are between 18 and 85 years old - OR you have been diagnosed with PBC (primary biliary cholangitis) and are between 18 and 85 years old - You meet standard diagnostic criteria for your condition - You are willing to provide biological samples **You may NOT be eligible if...** - You do not have a confirmed diagnosis of PSC or PBC - You are under 18 or over 85 years old - Certain sample types cannot be collected from you (e.g., bile collection after liver transplant) Talk to your doctor to see if this trial is right for you.