Bariatric Surgery and Pharmacokinetics of Apixaban
Bariatric Surgery and Pharmacokinetics of Apixaban: BAR-MEDS Apixaban
Norwegian University of Science and Technology
12 participants
Jan 2, 2018
OBSERVATIONAL
Conditions
Summary
Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study we investigate the pharmacokinetic effects of bariatric surgery on apixaban.
Eligibility
Inclusion Criteria2
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
Exclusion Criteria1
- Having previously undergone resections in the GI-tract
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Interventions
Patients are tested for their normal prescription apixaban medication
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT03448783