RecruitingNot ApplicableNCT03458676

Radiologic Pathologic Correlation of Advanced MR Imaging to Guide the Biopsy of Cerebral Malignancies


Sponsor

M.D. Anderson Cancer Center

Enrollment

62 participants

Start Date

Sep 6, 2012

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical research study is to learn if using advanced magnetic resonance imaging (AMRI) will improve the targeting of brain tumor needle biopsies compared to the standard targeting techniques. Researchers also want to learn how the results of the images and biopsies compare to each other to try to improve the way researchers and radiologists use AMRI images. This is an investigational study. The perfusion scan is not FDA approved or commercially available. It is currently only being used in research. There will be no cost to you for the advanced MRI, additional anesthesia, special pathology stains, and/or gene testing for this study. Up to 50 patients will take part in this study. All will be enrolled at MD Anderson.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether advanced MRI techniques (including blood flow, water movement, and chemical analysis imaging) can accurately guide surgeons to the most dangerous areas within a brain tumor, improving biopsy precision. **You may be eligible if...** - You are over 18 years old - You have a brain lesion that is suspected to be or has already been confirmed as a primary brain tumor - You are scheduled for brain tumor surgery or biopsy - You are able to undergo MRI with contrast dye - You can understand and provide consent to participate **You may NOT be eligible if...** - Your anatomy makes a safe brain biopsy impossible - You have severe kidney disease (which makes contrast dye unsafe) - You have a pacemaker, metal implants in your head, or other devices incompatible with MRI - Your doctors determine that the brain scan cannot be safely performed Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREAdvanced Magnetic Resonance Imaging Scan

AMRI scan performed within 2 weeks before standard of care brain biopsy and tumor removal surgery. AMRI scan should take less than 1 hour to complete

PROCEDUREStandard of Care Brain Biopsy and Tumor Removal

During the surgery, the neurosurgeon(s) uses the information collected from the AMRI to decide what area of the brain tumor will be biopsied. Biopsies from up to 5 locations taken before the tumor is surgically removed.


Locations(1)

University of Texas MD Anderson Cancer Center

Houston, Texas, United States

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NCT03458676


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