RecruitingNot ApplicableNCT03586258

Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2

Anatomical Clinical Correlations. Neuropsychological and Brain Medical Imaging Study in Brain Damage Subjects 2 (CORAC2)


Sponsor

University Hospital, Caen

Enrollment

400 participants

Start Date

Jan 10, 2019

Study Type

INTERVENTIONAL

Conditions

Summary

Two groups of subjects will be constitute: (i) patients with circumscribed brain injury (including stroke, vascular malformations, tumor or circumscribed infectious lesions) or degenerative/developmental disorders and selective cognitive disorders; (ii) healthy control subjects. The objective of this project is to evaluate specific neuropsychological deficits and apply current brain imaging techniques (anatomical, diffusion, functional, magnetic stimulation) to patients suffering from these cognitive deficits due to brain damage, in order to elucidate the brain mechanisms underlying these deficits.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses neuropsychological testing and brain MRI scans to better understand how different types of brain damage — from strokes, tumors, developmental conditions, or other causes — affect thinking, memory, and other cognitive functions. By mapping how specific brain lesions relate to specific deficits, researchers aim to improve diagnosis and treatment planning. Both patients with documented brain damage and healthy volunteers are enrolled as comparison groups. Advanced brain imaging and cognitive tests are used to characterize these relationships. Participants must be French-speaking adults (18+), and patients must have a focal brain lesion or a developmental/degenerative condition with cognitive deficits. You may be eligible if you: - Are 18 years of age or older - Speak French - For patients: have a documented focal brain lesion (stroke, tumor, trauma, inflammation) or developmental/degenerative disease with cognitive deficits - For healthy volunteers: have no significant neurological or psychiatric history - Are able to provide informed consent You may NOT be eligible if you: - Have current severe depression or anxiety (patients) - Have significant visual or auditory impairment - Are taking psychotropic medications (other than low-dose hypnotics or anxiolytics) - Are currently pregnant or breastfeeding - Have a contraindication to MRI (e.g., metal implants, pacemaker) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALNeuropsychological testing

Experimental test about cognitive deficit of interest and standard neuropsychological tests

OTHERBrain Imaging

Anatomical, diffusion, and/or functional MRI

OTHERGalvanic Vestibular Stimulation (GVS)

Stimulation versus Sham


Locations(1)

Caen University Hospital

Caen, France

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NCT03586258


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