RecruitingNCT03480633

Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Preserved vs. Reduced Ejection Fraction Biomarker Registry and Precision Medicine Database for Ambulatory Heart Failure Patients (PREFER-HF) Study

Sponsor

Massachusetts General Hospital

Enrollment

3,000 participants

Start Date

Apr 7, 2016

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Reduced Ejection Fraction Cardiovascular Risk Factor Heart Failure With Mid Range Ejection Fraction Heart Failure With Normal Ejection Fraction Heart Failure, Right Sided

Summary

In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This registry study is enrolling patients with and without heart failure to collect detailed measurements of how the heart pumps and moves, using advanced imaging and testing, to build a database that will help doctors better predict and personalize heart failure care. **You may be eligible if...** - You are 18 or older - You have a history of heart failure symptoms AND supporting medical evidence such as elevated heart failure blood markers (BNP or NT-proBNP), abnormal pressure measurements from a heart catheterization procedure, or imaging evidence of fluid backup in the lungs - Both types of heart failure qualify: heart failure with preserved pumping function (HFpEF, ejection fraction ≥50%) and heart failure with reduced pumping function (HFrEF, ejection fraction <50%) **You may NOT be eligible if...** - You have end-stage kidney disease and are on dialysis Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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