RecruitingNCT03775577

Exercise Intolerance in Heart Failure

Exercise Intolerance in Heart Failure: the Role of Altered Cardiac and Skeletal Muscle Energetics


Sponsor

Johns Hopkins University

Enrollment

130 participants

Start Date

Apr 1, 2017

Study Type

OBSERVATIONAL

Conditions

Summary

The investigators are studying whether metabolic abnormalities in cardiac and skeletal muscle in patients with heart failure with preserved ejection fraction (HFpEF) are associated with debilitating exercise intolerance.


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating the specific physiological reasons why people with heart failure — a condition where the heart cannot pump blood effectively — struggle to exercise. Researchers will monitor heart, lung, and muscle function carefully during physical activity to identify which components of the cardiovascular and respiratory systems are most responsible for limiting exercise capacity. Understanding these mechanisms could lead to more targeted treatments that help heart failure patients become more active and improve their quality of life. **You may be eligible if...** - You are over 21 years of age (any gender), with no upper age limit - Your treating cardiologist has approved your participation - You have had a confirmed diagnosis of heart failure with NYHA Class II or III symptoms (meaning you have symptoms during regular or mild physical activity) for at least one month - Your heart's pumping function has been formally measured **You may NOT be eligible if...** - You have unstable heart failure or have been recently hospitalized for heart problems - You have other severe medical conditions that make exercise testing unsafe - Your physician does not approve your participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Johns Hopkins Hospital

Baltimore, Maryland, United States

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NCT03775577


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