Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

This study is comparing two types of knee injections — platelet-rich plasma (PRP), made from the patient's own blood, and hyaluronic acid (HA), a lubricating gel — to see which is more effective at reducing pain, improving function, and preserving cartilage in people with knee osteoarthritis. Researchers will use MRI scans to measure cartilage thickness at baseline and at 12 months, and questionnaires to track pain and function over time. Adults aged 18 to 75 with moderate knee osteoarthritis (grade 2–3), significant pain (40+ on a 100-point scale), and normal blood counts are eligible — those with diabetes, autoimmune disorders, prior knee surgery in the last year, or who are pregnant are excluded. Participation involves receiving one knee injection and attending follow-up visits at 1, 3, 6, and 12 months after treatment, including one MRI scan at 6 and 12 months. This summary was prepared with AI assistance to help patients understand the study in plain language.