RecruitingNCT03512132

Study of High Density Lipoprotein Function in Type 1 Diabetic Patients With Nephropathy

Sponsor

Centre Hospitalier Universitaire Dijon

Enrollment

200 participants

Start Date

Apr 24, 2018

Study Type

OBSERVATIONAL

Conditions

Type 1 Diabetes

Summary

A number of arguments suggest that the deterioration in high density lipoproteins (HDL) functioning may worsen with the development of nephropathy during type 1 diabetes (T1D). The objective of this study will be to investigate to what extent nephropathy in T1D patients in the microalbuminuria and macroalbuminuria stages, compared to T1D patients without nephropathy, is associated with an alteration in HDL functionality and changes in HDL size and composition (lipids with detailed study of phosphates and sphingolipids, main lipoproteins, inflammatory markers).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying how HDL cholesterol (often called "good cholesterol") functions differently in people with type 1 diabetes who have varying levels of kidney damage, to understand how diabetes affects heart-protective processes in the body. **You may be eligible if...** - You are over 18 years old - You have type 1 diabetes (diagnosed based on your medical history, specific antibodies, or a low insulin production test), OR you do not have diabetes and are willing to serve as a healthy comparison participant - If you have type 1 diabetes, your blood sugar control (HbA1c) is between 6% and 9% - Your kidney function is within an acceptable range **You may NOT be eligible if...** - You have type 2 diabetes or another form of diabetes (such as MODY or mitochondrial diabetes) - Your blood sugar control, cholesterol levels, or kidney function fall outside the required ranges - You are unable or unwilling to provide consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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