Fecal Microbiota Transplantation for Pouchitis

Pouchitis is inflammation of the internal pouch created in patients who have had surgery to remove their colon (often due to ulcerative colitis or familial polyposis). It causes diarrhea, urgency, and abdominal pain, and can significantly affect quality of life. This study tests fecal microbiota transplantation (FMT) — transferring healthy gut bacteria from a donor — as a treatment for active pouchitis. The idea is that restoring a healthy balance of gut microbes may calm the inflammation driving pouchitis. FMT has shown promise in recurrent Clostridioides difficile infection and researchers believe it may work in pouchitis by rebalancing the disrupted microbiome of the pouch. You may be eligible if: - You are 18 years old or older - You have a confirmed internal pouch - You have active pouchitis with a PDAI score between 7 and 18 - You are willing to use contraception if you are a woman of childbearing potential You may NOT be eligible if: - You are already participating in another clinical trial - You cannot provide informed consent - You have a severe medical illness - You have an active Clostridioides difficile (C. diff) infection Talk to your doctor to see if this trial is right for you.